The mechanisms of compensation of aberration between cornea and lens are somehow modified during both accommodation and aging. In 15 individualized ocular models of young and unaccommodated eyes, we used morphological data of the lens to simulate the effect of accommodation and aging on these mechanisms. The predicted changes in aberrations were compared to data from the literature. In general, only the variation of the lens curvature was enough to reproduce the decrease in ocular spherical aberration (SA) during accommodation. However, the increase in SA with age could only be explained as a consequence of an increase in the conic constant of the lens and/or additional changes on the gradient index.