A new concept for high-resolution ophthalmoscopy is presented. The method is an alternative to the use of adaptive optics. It is based in deconvolving a retinal image from simultaneously acquired multiple ocular wave-front aberration and aberration-distorted fundus images. A computer simulation of the procedure using actual ocular wave-front aberration data that shows the validity of the method is first presented. Experimental results obtained from an artificial eye serve both to probe the method in a situation similar to the real eye and to introduce the required preprocessing of the retinal images. Finally, results from a real human retina are presented, and the potential of the technique is discussed. © 2000 Optical Society of America OCIS codes: 330.0330, 330.4300, 100.0100, 100.1830.