Purpose: To compare different methodologies to predict defocus curves of pseudophakic patients, and to compare these predictions with clinically-obtained defocus curves.
Methods: The through-focus performance of the pseudophakic eye was evaluated in laboratory and clinical settings. Measurements included computer-simulated defocus curves, through-focus image quality testing on an optical bench, and defocus curves obtained for subjects using an adaptive optics vision simulator (AOVS). The results were compared to available clinically obtained defocus curves of two intraocular lens designs.
Results: Predicted visual acuity at distance was better than 0.0 logMAR for the two methods that determined visual acuity (simulations, AOVS). This corresponded with the clinical results. For eyes implanted with an extended range of vision IOL, the simulations and AOVS predicted the clinically‑obtained defocus curve within 0.1 logMAR up to and including ‑2.0 diopters of defocus. For higher values of defocus, the simulations overestimated the clinically obtained visual acuity, and the AOVS slightly underestimated the clinically obtained visual acuity. Correlation of the image quality on the optical bench and the clinically‑obtained defocus curves varied, depending on the spatial frequency evaluated.
Conclusions: Simulation of defocus curves and measurements using an AOVS correspond well with clinically‑obtained defocus curves. Prediction of defocus curves using through-focus image quality measured on an optical bench depends on the spatial frequency content evaluated.